Reacción #2069276

Ecuación de reacción

acetic acid

2,2-dimethyl-1,3-benzodioxole-4-sulfonamide

trimethylaluminum

methyl[4-methoxy-6-methyl-1,3,5-triazin-2-yl]carbamate

→

white solid

Rendimiento 7.2%

N-[(4-Methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]-2,2-dimethyl-1,3-benzodioxole-4-sulfonamide

Rendimiento 7.2%

Disolventes

methylene chloride

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwas added
2. 2
   Temperaturathe reaction mixture was heated
3. 3
   Temperaturaat reflux 72 hours
4. 4
   TemperaturaThe reaction mixture was cooled to room temperature
5. 5
   OtroThe organic phase was separated
6. 6
   Otrodried
7. 7
   Otrothe solvent removed under reduced pressure
8. 8
   Otroto give an oil
9. 9
   OtroCrystallization of the oil
10. 10
    workup.ADDITIONfrom a mixture of ether, methylene chloride, and hexane

Procedimiento

To a solution of 1.0 g 2,2-dimethyl-1,3-benzodioxole-4-sulfonamide, prepared in Example 1, in 50 ml methylene chloride at room temperature under nitrogen was added 2.5 ml trimethylaluminum (2M in toluene). After stirring 15 minutes at room temperature, 0.7 g of methyl[4-methoxy-6-methyl-1,3,5-triazin-2-yl]carbamate, prepared according to the procedure of Example 5, was added and the reaction mixture was heated at reflux 72 hours. The reaction mixture was cooled to room temperature and 75 ml ice, 3 ml glacial acetic acid, and 10 drops of hydrochloric acid were sequentially added. The organic phase was separated, dried and the solvent removed under reduced pressure to give an oil. Crystallization of the oil from a mixture of ether, methylene chloride, and hexane gave 0.1 g white solid, m.p. 160°-168° C. The infrared spectrum showed a carbonyl absorption at 1705 cm-1 indicative of the title compound.

Fuente