Reacción #2067485

Ecuación de reacción

2-cyanoacetamide

2-(4-chlorophenyl)-3-(dimethylamino)acrolein

→

5-(4-CHLOROPHENYL)-3-CYANO-2-(1H)-PYRIDONE

Disolventes

Sodium

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwas added
2. 2
   TemperaturaThe mixture was refluxed for 1 hour
3. 3
   Filtraciónthe resulting precipitate was filtered
4. 4
   Lavadowashed with ethanol
5. 5
   workup.DISSOLUTIONdissolved in hot water
6. 6
   FiltraciónThe resulting precipitate was filtered
7. 7
   Lavadowashed with water

Procedimiento

Sodium (7 grams in 300 ml methanol) was stirred while a methanolic solution of 2-cyanoacetamide (16 grams) and 2-(4-chlorophenyl)-3-(dimethylamino)acrolein (37 grams) was added. The mixture was refluxed for 1 hour and the resulting precipitate was filtered, washed with ethanol, dissolved in hot water, and then acidified. The resulting precipitate was filtered, washed with water, and identified as the desired product, m.p. 278°-280° C.

Fuente