Reacción #2065798

Ecuación de reacción

sodium thiosulfate

1,4-benzodioxane

sodium carbonate

bromine

→

6-bromo-2,3-dihydro-1,4-benzodioxine

Disolventes

hexane

hexane

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónthe mixture was extracted with ethyl acetate
2. 2
   LavadoThe organic layer was washed with saturated brine
3. 3
   Secadodried with magnesium sulfate
4. 4
   Concentraciónconcentrated under reduced pressure

Procedimiento

To a mixture of 1,4-benzodioxane (5.0 g) and sodium carbonate (5.9 g) in hexane (100 ml) was added dropwise at room temperature a solution of bromine (1.9 ml) in hexane (20 ml) for 1 hour and the mixture was stirred for 1 hour. To the mixture was added an aqueous solution of sodium thiosulfate, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried with magnesium sulfate and concentrated under reduced pressure to give orange oil of 6-bromo-2,3-dihydro-1,4-benzodioxine (7.48 g).

Fuente