Reacción #2065001

Ecuación de reacción

2-bromo-6-(4-trifluoromethylphenyl)indan-1-one

thiourea

→

hydrobromide

2-Amino-5-(4-trifluoromethylphenyl)-8,8a-dihydroindeno[1,2-d]thiazol-3a-ol hydrobromide

2-amino-5-(4-trifluoromethylphenyl)-8,8a-dihydroindeno[1,2-d]thiazol-3a-ol

Disolventes

acetone

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe precipitate is filtered off with suction
2. 2
   Lavadowashed with acetone
3. 3
   Otrodried in vacuo

Procedimiento

1.06 g of 2-bromo-6-(4-trifluoromethylphenyl)indan-1-one are dissolved with 266 mg of thiourea in 10 ml of dry acetone and stirred at ice-bath temperature for 4 h. The precipitate is filtered off with suction, washed with acetone and dried in vacuo. The hydrobromide of 2-amino-5-(4-trifluoromethylphenyl)-8,8a-dihydroindeno[1,2-d]thiazol-3a-ol is obtained with a melting point of 228-230° C.

Fuente