Reacción #2063060

Ecuación de reacción

1-(3,4-dichlorophenyl)piperazine

5-chloropentanenitrile

sodium carbonate

→

4-(3,4-dichlorophenyl)-1-piperazinepentanenitrile

Rendimiento 72.1%

Disolventes

4-methyl-2-pentanone

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturarefluxed for 10 hours
2. 2
   TemperaturaThe reaction mixture was cooled
3. 3
   Filtraciónfiltered
4. 4
   Otrothe filtrate was evaporated
5. 5
   OtroThe residue was purified by column chromatography over silica gel (eluent: CH2Cl2/CH3OH 95/5)
6. 6
   OtroThe pure fractions were collected
7. 7
   Otrothe solvent was evaporated

Procedimiento

A mixture of 1-(3,4-dichlorophenyl)piperazine (0.1 mol), 5-chloropentanenitrile (0.13 mol), sodium carbonate (10 g) and potassium iodide (0.1 g) in 4-methyl-2-pentanone (280 ml) was stirred and refluxed for 10 hours. The reaction mixture was cooled, filtered and the filtrate was evaporated. The residue was purified by column chromatography over silica gel (eluent: CH2Cl2/CH3OH 95/5). The pure fractions were collected and the solvent was evaporated, yielding 22.5 g (72%) of 4-(3,4-dichlorophenyl)-1-piperazinepentanenitrile (interm. 2).

Fuente