Reacción #2045108

Ecuación de reacción

1-methyl-2-trichloroacetyl-1H-pyrrole

nitric acid

→

1-Methyl-4-nitro-2-trichloroacetyl-1H-pyrrole

Disolventes

acetic anhydride

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe mixture is slowly warmed to RT
2. 2
   workup.STIRRINGstirred vigorously for 2.5 h (initially oily deposit
3. 3
   Otrocrystallization)
4. 4
   FiltraciónThe precipitate is filtered off with suction
5. 5
   Otrotriturated with 20 ml of methanol
6. 6
   Filtraciónfiltered
7. 7
   Otrodried under reduced pressure overnight
8. 8
   OtroTo remove the regioisomers, which
9. 9
   Otroare also formed
10. 10
    Otrothe product is triturated with 10 ml of acetic acid/water 1:1 for 2 h
11. 11
    Filtraciónthe solid is filtered off with suction
12. 12
    Otrodried under reduced pressure
13. 13
    OtroThis gives a solid

Procedimiento

2.12 g (9.34 mmol) of 1-methyl-2-trichloroacetyl-1H-pyrrole are dissolved in 9.5 ml of acetic anhydride and cooled to −20° C., and 0.43 ml (9.34 mmol) of nitric acid is added. The mixture is slowly warmed to RT and stirred at RT for 1 h. The reaction mixture is poured into 95 g of ice and stirred vigorously for 2.5 h (initially oily deposit then crystallization). The precipitate is filtered off with suction, triturated with 20 ml of methanol, filtered and dried under reduced pressure overnight. To remove the regioisomers, which are also formed, the product is triturated with 10 ml of acetic acid/water 1:1 for 2 h, and the solid is filtered off with suction and dried under reduced pressure. This gives a solid.

Fuente