Reacción #2045039

Ecuación de reacción

6-(4-nitrophenoxy) hexanoic acid methyl ester

6-(4-Nitro-phenoxy)-hexanoic acid methyl ester

→

53

Rendimiento 80.2%

6-(4-Nitrophenoxy)-hexanoic acid

Rendimiento 80.2%

Disolventes

HCl

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas refluxed for 16 hours
2. 2
   Filtraciónfiltered
3. 3
   Otrodried
4. 4
   Otrorecrystallised from a mixture of ethyl acetate:hexane (1:6)

Procedimiento

A mixture of 6-(4-nitrophenoxy) hexanoic acid methyl ester 39 (125 g, 468.16 mmol) and concentrated HCl (1250 ml) was refluxed for 16 hours. The reaction mixture was cooled to room temperature, filtered, dried and recrystallised from a mixture of ethyl acetate:hexane (1:6) to get pure 53 (95 g, 80.2%) as a white powder. M.p: 104-107° C.

Fuente