Reacción #2045033

Ecuación de reacción

(4-Aminophenoxy)acetic acid methyl ester

(4-Nitro-phenoxy)-acetic acid-2-hydroxy-ethyl ester

→

46

Rendimiento 22.8%

(4-Amino-phenoxy)-acetic acid 2-hydroxy-ethyl ester

Rendimiento 22.8%

Disolventes

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe catalyst was removed by filtration, ethyl acetate
2. 2
   workup.DISTILLATIONwas distilled off
3. 3
   workup.ADDITIONhexane was added
4. 4
   FiltraciónThe solid product was filtered
5. 5
   Otrodried

Procedimiento

(4-Aminophenoxy)acetic acid methyl ester 41 (1 g, 4.15 mmol) was dissolved in ethyl acetate in a pressure vessel, palladium on carbon (5%, 0.5 g) was added and the mixture was stirred under an atmosphere of hydrogen (0.5 Kg) for one hour. The catalyst was removed by filtration, ethyl acetate was distilled off and hexane was added. The solid product was filtered and dried to give pure 46 (0.2 g, 22.8%) as a brown powder. M.p: 104-106.3° C.

Fuente