Reacción #2045025

Ecuación de reacción

6-(4-Isocyanato-phenoxy)-hexanoic acid methyl ester

ethylene glycol

→

37

Rendimiento 84.0%

6-[4-(2-Hydroxy-ethoxycarbonylamino)-phenoxy]-hexanoic acid methyl ester

Rendimiento 84.0%

Disolventes

Water

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrorose to 46° C
2. 2
   Filtracióncrude 37 was filtered
3. 3
   Otrodried
4. 4
   Otrorecrystallised from toluene

Procedimiento

6-(4-Isocyanato-phenoxy)-hexanoic acid methyl ester 36 (15 g, 57 mmol) was added to ethylene glycol (50 ml) at room temperature. The reaction was exothermic and the temperature rose to 46° C. The reaction mixture was allowed to cool to room temperature and later stirred at room temperature for 16 hours. Water (150 ml) was added and crude 37 was filtered, dried and recrystallised from toluene to get pure 37 (12 g, 84%) as a white powder. M.p: 69.5-71.5° C.

Fuente