Reacción #2045020

Ecuación de reacción

4-Nitro phenol

K2CO3

methyl chloroacetate

→

31

Rendimiento 72.5%

Methyl(4-Nitro phenoxy)acetate

Rendimiento 72.5%

Disolventes

acetone

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturarefluxed for 12 hours
2. 2
   workup.DISTILLATIONAcetone was distilled off
3. 3
   workup.ADDITIONwater (1500 ml) added
4. 4
   FiltraciónCrude 31 was filtered
5. 5
   Otrodried
6. 6
   Otrorecrystallised from a mixture of ethyl acetate:hexane (1:5)

Procedimiento

To a mixture of 4-Nitro phenol (100 g, 719 mmol) and anhydrous K2CO3 (400 g, 2.894 moles) in anhydrous acetone (950 ml) was added methyl chloroacetate (114 g, 1.050 moles) and refluxed for 12 hours. Acetone was distilled off and water (1500 ml) added. Crude 31 was filtered, dried and recrystallised from a mixture of ethyl acetate:hexane (1:5) to give pure 31 (110 g, 72.5%) as a white fluffy powder. M.p: 97-98.4° C.

Fuente