Reacción #2045018

Ecuación de reacción

(4-Isocyanato-phenoxy)-acetic acid methyl ester

ethylene glycol

→

29

Rendimiento 82.9%

[4-(2-Hydroxy-ethoxycarbonylamino)-phenoxy]-acetic acid methyl ester

Rendimiento 82.9%

Disolventes

Water

Condiciones de reacción

Tratamiento posterior

1. 1
   Filtracióncrude 29 was filtered
2. 2
   Otrodried
3. 3
   Otropurified by column chromatography on silica gel

Procedimiento

(4-Isocyanato-phenoxy)-acetic acid methyl ester 28 (15 g, 72.46 mmol) was added to ethylene glycol (30 ml) at room temperature. The reaction was exothermic and the temperature raised to 42° C. Later the reaction mixture was stirred at room temperature for 16 hours. Water (100 ml) was added and crude 29 was filtered, dried and purified by column chromatography on silica gel using chloroform as eluant to get pure 29 (16.17 g, 82.9%) as a off-white powder. M.p: 85.5-87.5° C.

Fuente