Reacción #2045014

Ecuación de reacción

Benzyloxyacetic acid 4-acetylamino-phenyl ester

Benzyloxy-acetic acid 4-acetylamino-phenyl ester

→

25

Rendimiento 57.4%

Hydroxy-acetic acid 4-acetylamino-phenyl ester

Rendimiento 57.4%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe catalyst was removed by filtration
2. 2
   workup.DISTILLATIONthe methanol was then distilled off
3. 3
   OtroThe crude 25 was recrystallized from mixture of chloroform:methanol (1:4)

Procedimiento

Benzyloxyacetic acid 4-acetylamino-phenyl ester 24 (15 g, 50 mmol) was dissolved in methanol (150 ml) in a pressure vessel, palladium on carbon (5%, 8 grams) added and the mixture stirred under an atmosphere of hydrogen (3 Kg) for 20 hours. The catalyst was removed by filtration and the methanol was then distilled off. The crude 25 was recrystallized from mixture of chloroform:methanol (1:4) to get pure 25 (6 g, 57.2%) as a white powder. M.p: 144-146° C.

Fuente