Reacción #2045004

Ecuación de reacción

(4-Acetylamino-phenoxy)-acetic acid ethyl ester

hydrochloric acid

→

14

Rendimiento 77.6%

(4-Amino-phenoxy)acetic acid HCl

Rendimiento 77.6%

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.DISTILLATIONExcess concentrated hydrochloric acid was distilled off in vacuum
2. 2
   Filtraciónfiltered hot
3. 3
   Filtraciónfiltered
4. 4
   Otrodried

Procedimiento

A mixture (4-Acetylamino-phenoxy)-acetic acid ethyl ester 13 (375 g, 1.582 mmol), in concentrated hydrochloric acid (9.36 liters) was refluxed for 12 hours. Excess concentrated hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 14 (250 g, 77.6%) as a wheat colored powder. The melting point was found to be 224-226° C. The structure was confirmed with NMR.

Fuente