Reacción #2040203

ord-3c07ca727a834e448dc087735197312d

Ecuación de reacción

CCCCc1ccc(C(=O)O)cc1
4-butyl-benzoic acid
Cl.NC(=O)NCc1ccc(CNC(=O)[C@H](N)CCCNC(N)=N[N+](=O)[O-])cc1
(R)-N-[[4-(aminocarbonylaminomethyl)phenyl]methyl]-N5 -[amino(nitroimino)methyl]-ornithinamide-hydrochloride
CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
TBTU
→
CCCCc1ccc(C(=O)N[C@H](CCCNC(N)=N[N+](=O)[O-])C(=O)NCc2ccc(CNC(N)=O)cc2)cc1
(R)-N-[[4-(Aminocarbonylaminomethyl)phenyl]methyl]-N5 -[amino(nitroimino)methyl]-N2 -(4-butylbenzoyl)-ornithinamide
Rendimiento 33.0%

Reactantes

CCCCc1ccc(C(=O)O)cc1
4-butyl-benzoic acid
Cl.NC(=O)NCc1ccc(CNC(=O)[C@H](N)CCCNC(N)=N[N+](=O)[O-])cc1
(R)-N-[[4-(aminocarbonylaminomethyl)phenyl]methyl]-N5 -[amino(nitroimino)methyl]-ornithinamide-hydrochloride
CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
TBTU

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Prepared analogously to Example 69a) from 4-butyl-benzoic acid, (R)-N-[[4-(aminocarbonylaminomethyl)phenyl]methyl]-N5 -[amino(nitroimino)methyl]-ornithinamide-hydrochloride and TBTU in a yield of 33% of theory.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US06114390uspto-grants-2000_09