Reacción #2040016

Ecuación de reacción

product

1,3-diphenyl-5,6-dimethyl-4,7-dihydro-2H-isoindole

ammonium format

→

expected product

1,3-diphenyl-5,6-dimethyl-4,5,6,7-tetrahydro-2H-isoindole

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaat reflux for 3 hours
2. 2
   Filtraciónfiltered
3. 3
   Concentraciónconcentrated

Procedimiento

1 g of the product obtained in Example 6, 1.2 g of ammonium format and 0.2 g of 10% Pd/C in 70 ml of ethanol are heated at reflux for 3 hours, then filtered and concentrated. The expected product is isolated by chromatography on silica gel (eluant: cyclohexane/ethyl acetate: 90/10).

Fuente