Reacción #2028892

Ecuación de reacción

compound

4-[4-bromomethyl-5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide

collidine

dimethyl sulfoxide

→

desired product

Rendimiento 66.0%

4-[4-formyl-5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide

Rendimiento 66.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe reaction solution was partitioned between ethyl acetate and water
2. 2
   Lavadothe organic solution was washed with water
3. 3
   Otrodried
4. 4
   Concentraciónconcentrated
5. 5
   OtroThe residue was chromatographed (1:1 hexane:ethyl acetate)

Procedimiento

To a solution of the compound prepared in Step 1 (362 mg, 0.79 mmol) in dimethyl sulfoxide (7 mL) was added collidine (0.14 mL, 1.0 mmol). The solution was heated at 120° C. for 3 hours and then kept at overnight at room temperature. The reaction solution was partitioned between ethyl acetate and water and the organic solution was washed with water, dried and concentrated. The residue was chromatographed (1:1 hexane:ethyl acetate) to give the desired product (205 mg, 66%).

Fuente