Reacción #2028884

Ecuación de reacción

HCl

sodium methoxide

Ethyl trifluoroacetate

6-methyltetralone

→

oil

Rendimiento 85.1%

6-methyl-2-(trifluoroacetyl)tetralone

Rendimiento 85.1%

Disolventes

ether

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe organic layer was collected
2. 2
   Lavadowashed with brine
3. 3
   Secadodried over MgSO4
4. 4
   Concentraciónconcentrated in vacuo

Procedimiento

Ethyl trifluoroacetate (5.33 g, 37.5 mmol) was dissolved in ether (50 mL) and treated with a sodium methoxide solution (25% in methanol, 9.92 g, 45.9 mmol) followed by 6-methyltetralone (5.94 g, 37.1 mmol). The reaction was stirred at room temperature for 6.1 hours then treated with 1N HCl (20 mL). The organic layer was collected, washed with brine, dried over MgSO4, and concentrated in vacuo to give a brown oil (8.09 g) that was used in the next step without further purification.

Fuente