Reacción #2027

Ecuación de reacción

1,3-Dibromopropane

sodium sulfite

Norit

→

title compound

Rendimiento 85.6%

Sodium 1,3-propanedisulfonate

Rendimiento 85.6%

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThis compound was prepared by a modification of the method
2. 2
   Temperaturaat reflux temperature for 48 h
3. 3
   OtroInorganic salts (sodium bromide and sodium sulfite) were removed by successive treatment of the resultant
4. 4
   Otroreaction mixture with barium hydroxide and silver(I) oxide
5. 5
   OtroBarium ions were removed by treatment of the aqueous solution with Amberlite-120 (sodium form) ion-exchange resin
6. 6
   OtroThe solvent was removed on a rotary evaporator
7. 7
   Otrothe crude product was recrystallized from water-ethanol several times

Procedimiento

This compound was prepared by a modification of the method described in Stone, G. C. H. (1936) J. Am. Chem. Soc., 58:488. 1,3-Dibromopropane (40.4 g, 0.20 mol) was treated with sodium sulfite (60.3 g, 0.50 mol) in water at reflux temperature for 48 h. Inorganic salts (sodium bromide and sodium sulfite) were removed by successive treatment of the resultant reaction mixture with barium hydroxide and silver(I) oxide. The solution was then neutralized with Amberlite-120 (acid form) and decolorized with Norit-A. Barium ions were removed by treatment of the aqueous solution with Amberlite-120 (sodium form) ion-exchange resin. The solvent was removed on a rotary evaporator, and the crude product was recrystallized from water-ethanol several times to give the title compound (42.5 g). The small amount of trapped ethanol was removed by dissolving the crystals in a minimum amount of water and then concentrating the solution to dryness. The pure product was further dried under high vacuum at 56° C. for 24 h: mp>300° C.; 1H NMR (D2O) δ: 3.06-3.13 (m, 4H, H-1 and H-3), 2.13-2.29 (m, 2H, H-2); 13C NMR (D2O) δ: 52.3 (C-1 and C-3), 23.8 (C-2).

Fuente