Reacción #2026401

Ecuación de reacción

5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine

triethylamine

6-[(2-methylphenylacetyl)amino]pyridine-3-carbonyl chloride

→

product

N-[5-[(5,6,7,8-Tetrahydro-4H-thieno[3,2-b]azepin-4-yl)carbonyl]-2-pyridinyl]-2-methylbenzeneacetamide

Disolventes

dichloromethane

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaTo a cooled
2. 2
   LavadoThe mixture is washed with H2O, 1N NaHCO3, H2O, brine
3. 3
   Secadodried (Na2SO4)
4. 4
   ConcentraciónThe solution is concentrated to dryness under vacuum
5. 5
   Otrothe residue chromatographed on silica gel

Procedimiento

To a cooled (0° C.) mixture of 0.306 g of 5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine and 1.11 μl of triethylamine in 5 ml of dichloromethane is added 1.2 g of 6-[(2-methylphenylacetyl)amino]pyridine-3-carbonyl chloride. The mixture is stirred at room temperature for 16 hours and diluted with 50 ml of dichloromethane. The mixture is washed with H2O, 1N NaHCO3, H2O, brine and dried (Na2SO4). The solution is concentrated to dryness under vacuum and the residue chromatographed on silica gel to give the product as a solid.

Fuente