Reacción #2025289

Ecuación de reacción

hydrochloric acid

acetic acid anhydride

(+)-3-phenyl-1-butanol

toluene

→

(+)-1-acetoxy-3-phenylbutane

Rendimiento 99.0%

Disolventes

pyridine

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroInto a four-necked flask provided with a stirring means
2. 2
   OtroThe mixture was reacted for 4 hours while temperature
3. 3
   Temperaturabeing maintained at 40°-50° C
4. 4
   OtroAfter completion of the reaction
5. 5
   Extracciónextracted
6. 6
   LavadoThe resulting organic layer was washed with 1N hydrochloric acid, water, 5% sodium bicarbonate aqueous solution ad water in the order
7. 7
   ConcentraciónThe thus-obtained organic layer was concentrated under a reduced pressure

Procedimiento

Into a four-necked flask provided with a stirring means and a thermometer, 150 g (1 mol) of (+)-3-phenyl-1-butanol (XXVI-60), 500 ml of toluene and 200 ml of pyridine were charged, and 122.4 g (1.2 mol) of acetic acid anhydride and 1 g of 4-dimethylaminopyridine were further added thereto. The mixture was reacted for 4 hours while temperature being maintained at 40°-50° C. After completion of the reaction, the reaction mixture was poured into 500 ml of 4N hydrochloric acid, extracted and fractionated. The resulting organic layer was washed with 1N hydrochloric acid, water, 5% sodium bicarbonate aqueous solution ad water in the order. The thus-obtained organic layer was concentrated under a reduced pressure to obtain 190 g of (+)-1-acetoxy-3-phenylbutane (XXV-60) with yield of 99.0%.

Fuente