Reacción #2021467

Ecuación de reacción

HCl

4-fluorobenzaldehyde

malonic acid

piperidine

→

4-fluorocinnamic acid

Disolventes

pyridine

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturacooled
2. 2
   Concentracióna 10% concentration
3. 3
   FiltraciónThe precipitate is filtered
4. 4
   Otrocrystallized with ethanol

Procedimiento

A mixture of 0.1 mol 4-fluorobenzaldehyde, 0.15 mol malonic acid, and 0.1 ml piperidine in 30 ml pyridine is boiled for 10 hours, cooled, and treated with 150 ml HCl having a 10% concentration. The precipitate is filtered and crystallized with ethanol. The yield of 4-fluorocinnamic acid is 68% and the melting point is 211° C.

Fuente