Reacción #2014276
ord-79c6db1a90544de68e5b9d85966e9135
Ecuación de reacción
1-azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol
3-bromopropyl 4-fluorophenyl ether
→
desired product
Rendimiento 43.7%
1-{3-[(4-fluorophenyl)oxy]propyl}-4-[hydroxy(diphenyl)methyl]-1-azoniabicyclo[2.2.2]octane bromide
Rendimiento 43.7%
Reactivos
Ninguno
Disolventes
Condiciones de reacción
Condiciones detalladas
See reaction.notes.procedure_details.
Tratamiento posterior
- 1Otrowere reacted
Procedimiento
Following the general procedure outlined in Example 3, 1-azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol (0.0182 g, 0.0621 mmol) and 3-bromopropyl 4-fluorophenyl ether (0.0173 g, 0.0742 mmol) in 2 CH3CN/3 CHCl3 (4.0 mL) were reacted to give the desired product (0.0143 g, 43.7%). EI-MS m/z 446 (M+) Rt (1.96 min).