Reacción #2008593

ord-6e491a89e5ab45a29482c3ddfee195ef

Ecuación de reacción

CCc1cc(-c2ccc(S(=O)(=O)Cl)o2)c(C)[nH]c1=O
5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)furan-2-sulfonyl chloride
NCCCn1ccnc1
(3-imidazol-1-yl)propylamine
→
CCc1cc(-c2ccc(S(=O)(=O)NCCCn3ccnc3)o2)c(C)[nH]c1=O.Cl
title compound
Rendimiento 41.0%
CCc1cc(-c2ccc(S(=O)(=O)NCCCn3ccnc3)o2)c(C)[nH]c1=O.Cl
5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)furan-2-sulfonic acid (3-imidazol-1-yl)propylamide hydrochloride
Rendimiento 41.0%

Reactantes

CCc1cc(-c2ccc(S(=O)(=O)Cl)o2)c(C)[nH]c1=O
5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)furan-2-sulfonyl chloride
NCCCn1ccnc1
(3-imidazol-1-yl)propylamine

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)furan-2-sulfonyl chloride is reacted with (3-imidazol-1-yl)propylamine as described in Steps 5 and 6, Example 24 to give the title compound as a solid (41% yield). LC/MS: RT 1.54 min; m/e 391 (M+H).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US08173682B2uspto-grants-2012_05