Reacción #2006413

Ecuación de reacción

NaHCO3

Na2CO3

4-(4-aminophenyl)-butyric acid

HCl

→

40

Rendimiento 91.0%

Methyl-4-(4-aminophenyl)-butanoate

Rendimiento 91.0%

Disolventes

MeOH

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe solvent was evaporated under reduced pressure
2. 2
   Extracciónthe aqueous phase was extracted several times with CH2Cl2
3. 3
   OtroThe crude material was purified by flash chromatography

Procedimiento

To a solution of 4-(4-aminophenyl)-butyric acid (5 g, 27.90 mmol) in MeOH (100 mL) at room temperature was added HCl conc. (37% 15 mL). The resulting mixture was stirred overnight at 50° C. then treated with a saturated aqueous solution NaHCO3 and Na2CO3 solid until pH 9. The solvent was evaporated under reduced pressure then the aqueous phase was extracted several times with CH2Cl2. The crude material was purified by flash chromatography using CH2Cl2/MeOH as solvent mixture yielding 40 (4.93 g, 91%) as orange solid.

Fuente