Reacción #2000296

ord-788e5676d9874512b5a4a6102cc635ac

Ecuación de reacción

Cl.N[C@H]1CC[C@@H](Oc2cc3ccnc(O)c3cc2Cl)CC1
6-(cis-4-amino-cyclohexyloxy)-7-chloro-isoquinolin-1-ol hydrochloride
CC(C)(C)OC(=O)N[C@H]1CC[C@@H](O)CC1
cis-(4-hydroxy-cyclohexyl)-carbamic acid tert-butyl ester
Fc1ccc2c(Cl)nccc2c1Cl
1,5-dichloro-6-fluoro-isoquinoline
Fc1ccc2c(Cl)nccc2c1Cl
1,5-Dichloro-6-fluoro-isoquinoline
Cl
hydrochloride
→
N[C@H]1CC[C@@H](Oc2ccc3c(=O)[nH]ccc3c2Cl)CC1
title compound
N[C@H]1CC[C@@H](Oc2ccc3c(=O)[nH]ccc3c2Cl)CC1
6-(cis-4-Amino-cyclohexyloxy)-5-chloro-2H-isoquinolin-1-one

Reactantes

Cl.N[C@H]1CC[C@@H](Oc2cc3ccnc(O)c3cc2Cl)CC1
6-(cis-4-amino-cyclohexyloxy)-7-chloro-isoquinolin-1-ol hydrochloride
CC(C)(C)OC(=O)N[C@H]1CC[C@@H](O)CC1
cis-(4-hydroxy-cyclohexyl)-carbamic acid tert-butyl ester
Fc1ccc2c(Cl)nccc2c1Cl
1,5-dichloro-6-fluoro-isoquinoline
Fc1ccc2c(Cl)nccc2c1Cl
1,5-Dichloro-6-fluoro-isoquinoline
Cl
hydrochloride

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Starting from cis-(4-hydroxy-cyclohexyl)-carbamic acid tert-butyl ester and 1,5-dichloro-6-fluoro-isoquinoline (9), the title compound was prepared as hydrochloride following the route described for 6-(cis-4-amino-cyclohexyloxy)-7-chloro-isoquinolin-1-ol hydrochloride (10). Rt=1.04 min (Method B). Detected mass: 293.1/295.1 (M+H+).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US08609691B2uspto-grants-2013_12