Reacción #2000293

Ecuación de reacción

7-chloro-6-fluoro-isoquinoline 2-oxide

7-Chloro-6-fluoro-isoquinoline 2-oxide

POCl3

→

title compound

1,7-Dichloro-6-fluoro-isoquinoline

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaat reflux for 4 h
2. 2
   workup.ADDITIONit was poured on ice
3. 3
   ExtracciónThe aqueous solution was extracted three times with dichloromethane
4. 4
   SecadoThe combined organic layers were dried with magnesium sulfate
5. 5
   Otroevaporated

Procedimiento

2.6 g (12.0 mmol) of 7-chloro-6-fluoro-isoquinoline 2-oxide (5) were heated in 40 ml of POCl3 at reflux for 4 h. After the mixture has cooled down to room temperature, it was poured on ice. The aqueous solution was extracted three times with dichloromethane. The combined organic layers were dried with magnesium sulfate and evaporated to yield 2.91 g of the title compound, which was used without further purification. Rt=2.34 min (Method A). Detected mass: 216.0/218.0 (M+H+).

Fuente