Reacción #1998

Ecuación de reacción

Water

triethylamine

5-phenyltetrazole

triphenylmethyl chloride

→

product

Rendimiento 100.0%

5-Phenyl-2-trityltetrazole

Rendimiento 100.0%

Disolventes

acetone

tetrahydrofuran

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGthe mixture stirred for one hour at room temperature
2. 2
   FiltraciónThe product was collected by filtration
3. 3
   Lavadowashed with 75 mL of water
4. 4
   Otrodried at 60° C. under vacuum

Procedimiento

To a suspension of 5.0 g (34.2 mmol) of 5-phenyltetrazole in 55 mL of acetone was added 5.0 mL of triethylamine (3.6 g, 35.6 mmol, 1.04 eq). After 15 minutes, a solution of 10.0 g of triphenylmethyl chloride (35.9 mmol, 1.05 eq) in 20 mL of tetrahydrofuran was added and the mixture stirred at room temperature for one hour. Water (75 mL) was slowly added and the mixture stirred for one hour at room temperature. The product was collected by filtration, washed with 75 mL of water and dried at 60° C. under vacuum to give 13.3 g (34.2 mmol, 100%) of the product.

Fuente