Reacción #1994287

Ecuación de reacción

Tin (II) chloride

1,2-dichloro-4-fluoro-5-nitrobenzene

sodium bicarbonate

→

title compound

4,5-Dichloro-2-fluorophenylamine

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturato near reflux during the addition
2. 2
   Temperaturaupon cooling
3. 3
   Extracciónextracted with ethyl acetate
4. 4
   LavadoThe organic phase was washed several more times with water
5. 5
   Otrodried
6. 6
   Filtraciónfiltered
7. 7
   Concentraciónconcentrated

Procedimiento

Tin (II) chloride dehydrate (27.0 g, 119.6 mmol) was dissolved in ethanol and 1,2-dichloro-4-fluoro-5-nitrobenzene (5.0 g, 23.8 mmol) was added dropwise. Temperature rose to near reflux during the addition and was complete upon cooling. The reaction mixture was carefully added to saturated aqueous sodium bicarbonate and then extracted with ethyl acetate. The organic phase was washed several more times with water, dried, filtered and concentrated to give the title compound as a yellow solid: 1H NMR (CDCl3): δ 7.17 (d, 1H), 6.84 (d, 1H), 3.78 (br s, 2H).

Fuente