Reacción #1994258

Ecuación de reacción

10-(biphenyl-4-yl)-9,10-dihydroacridine

bromosuccinimide

→

10-(biphenyl-4-yl)-2-bromo-9,10-dihydroacridine

Rendimiento 77.7%

Disolventes

chloroform

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadothe resultant solution was washed with distilled water
2. 2
   ExtracciónThen, an organic layer was extracted
3. 3
   Secadodried with sodium sulfate so as
4. 4
   Otroto remove the solvent
5. 5
   OtroThe residue was purified by silica gel column chromatography (methylene chloride/n-hexane (1/20))

Procedimiento

The obtained 10-(biphenyl-4-yl)-9,10-dihydroacridine (15.3 g, 45.9 mmol) was added with chloroform (500 ml), and then with bromosuccinimide (9.8 g, 55.1 mmol). The resultant solution was stirred at room temperature for 2 hours. After the reaction was completed, the resultant solution was washed with distilled water. Then, an organic layer was extracted and dried with sodium sulfate so as to remove the solvent. The residue was purified by silica gel column chromatography (methylene chloride/n-hexane (1/20)) to obtain 10-(biphenyl-4-yl)-2-bromo-9,10-dihydroacridine compound (white solid, 14.7 g, yield 77%).

Fuente