Reacción #1994226

Ecuación de reacción

Boc-Gly Rotigotine HCl

trifluoroacetic acid

→

Gly Rotigotine

Rendimiento 79.0%

Disolventes

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroall the volatiles were removed
2. 2
   Otroa rotary evaporator
3. 3
   workup.DISSOLUTIONThe residue (dark yellow) was dissolved in methanol
4. 4
   Otroprecipitated
5. 5
   workup.ADDITIONby adding into diethyl ether (40 mL)
6. 6
   FiltraciónThe pale yellow precipitate was filtered
7. 7
   Otrodried

Procedimiento

The Boc-Gly-Rotigotine HCl was deprotected by first dissolving the product (1.258 g, 2.55 mmol) in dichloromethane (64 ml). After addition of trifluoroacetic acid (9.83 ml, 128 mmol), the reaction mixture was stirred for 1 hour at room temperature and then all the volatiles were removed using a rotary evaporator. The residue (dark yellow) was dissolved in methanol and precipitated by adding into diethyl ether (40 mL). The pale yellow precipitate was filtered using a glass frit and dried to give Gly-Rotigotine.2TFA (1.140 g, 79% yield).

Fuente