Reacción #1991013

Ecuación de reacción

2,6-Difluoro-alpha-methylbenzyl alcohol

( B )

2,6-Difluoro-alpha-methylbenzyl alcohol

Thionyl chloride

→

title product

Rendimiento 99.8%

2,6-Difluoro-alpha-methylbenzyl chloride

Rendimiento 99.8%

Disolventes

chloroform

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroExcess thionyl chloride and chloroform are then removed on a rotary evaporator

Procedimiento

2,6-Difluoro-alpha-methylbenzyl alcohol of (B) (14.9 g, 0.094 mol) is dissolved in chloroform (50 ml) and warmed to 60° C. Thionyl chloride (22.4 g, 0.19 mol) is now added dropwise. The whole is kept at 60° C. for 4 hours then stirred overnight at room temperature. Excess thionyl chloride and chloroform are then removed on a rotary evaporator, resulting in pure title product (16.6 g, 99.8%).

Fuente