Reacción #1988397

Ecuación de reacción

3,4-dihydroxyphenylacetic acid

potassium carbonate

hydrogen chloride

bromoacetone

→

title compound

Methyl 3-hydroxy-4-(2-oxopropoxy)phenylacetate

Disolventes

dioxane

dimethylformamide

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothat described in Preparation 21

Procedimiento

Following a procedure similar to that described in Preparation 21, but using 10 g of 3,4-dihydroxyphenylacetic acid, 30 ml of absolute methanol, 20 ml of a 4N solution of hydrogen chloride in dioxane, 200 ml of anhydrous dimethylformamide, 8.74 g of bromoacetone and 8.02 g of potassium carbonate, the title compound was obtained having an Rf=0.37 (thin layer chromatography over silica gel, using a 1:2 by volume mixture of ethyl acetate and hexane as the developing solvent).

Fuente