Reacción #1985937

Ecuación de reacción

ammonium hydroxide

bis-[5-(2-methoxycarbonylethyl)-3-[5-(2-methoxycarbonylethyl)-2-hydroxybenzyl]2-hydroxyphenyl]methane

sodium hydroxide

→

desired product

Bis-[5-(2-carboxyethyl)-3-[5-(2-carboxyethyl)-2-hydroxybenzyl]2-hydroxyphenyl]methane

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe mixture is quenched with dilute aqueous hydrochloric acid (HCl)
2. 2
   OtroThe mixture is quenched as above and the organic soluble material flash
3. 3
   Otrochromatographed
4. 4
   Lavadoeluting with 10% methanol in chloroform
5. 5
   OtroThe product so obtained

Procedimiento

A solution of bis-[5-(2-methoxycarbonylethyl)-3-[5-(2-methoxycarbonylethyl)-2-hydroxybenzyl]2-hydroxyphenyl]methane (0.10 g) in methanol (2 ml) is stirred with 10% aqueous sodium hydroxide (NaOH) (1 ml) at room temperature. The mixture is quenched with dilute aqueous hydrochloric acid (HCl) and the organic soluble material retreated as above. The mixture is quenched as above and the organic soluble material flash chromatographed, eluting with 10% methanol in chloroform. The product so obtained is treated with ammonium hydroxide solution and lyophilized to give the desired product as the ammonium salt, m.p. 150° C. (dec.).

Fuente