Reacción #1985

Ecuación de reacción

compound

1-benzyl-3-trifluoromethylpyrrolidine-3-carboxylic acid

LAH

→

title compound

Rendimiento 99.9%

1-benzyl-3-trifluoromethylpyrrolidine-3-methanol

Rendimiento 99.9%

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe reaction was quenched by the sequential dropwise addition of 0.35 mL water, 0.35 mL of 15% NaOH and 1.3 mL of water
2. 2
   workup.STIRRINGthe mixture was stirred for 1 hour
3. 3
   Filtraciónfiltered
4. 4
   OtroThe filtrate was dried
5. 5
   Concentraciónconcentrated

Procedimiento

The compound from step 456a (2.32 g) was dissolved in 60 mL of dry THF, 1.12 eq of LAH (1N in dry THF) was added, and the reaction was stirred under N2 for 3 hours. The reaction was quenched by the sequential dropwise addition of 0.35 mL water, 0.35 mL of 15% NaOH and 1.3 mL of water, then the mixture was stirred for 1 hour and filtered. The filtrate was dried and concentrated to give 2.2 g of the title compound.

Fuente