Reacción #1973986

Ecuación de reacción

5-Bromoindoline

sodium hydride

Methanesulfonyl chloride

→

title compound

Rendimiento 61.0%

5-bromo-1-(methylsulfonyl)indoline

Rendimiento 61.0%

Disolventes

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGthe solution was stirred at room temperature for 30 min
2. 2
   workup.STIRRINGthe solution stirred at room temperature overnight
3. 3
   Concentraciónconcentrated in vacuo
4. 4
   OtroThe crude product was purified by column chromatography on silica gel eluting with 2% CH3OH/CHCl3

Procedimiento

To DMF (5.0 ml) was added sodium hydride (53 mg, 1.3 mmol) and the solution stirred at room temperature for 30 min. 5-Bromoindoline (240 mg, 1.2 mmol) was added and the solution was stirred at room temperature for 30 min. Methanesulfonyl chloride (94 ul, 1.2 mmol) was added and the solution stirred at room temperature overnight, then concentrated in vacuo. The crude product was purified by column chromatography on silica gel eluting with 2% CH3OH/CHCl3 to give the title compound (202 mg, 60%).

Fuente