Reacción #1973974

Ecuación de reacción

ethyl thioglycolate

4-bromo-2-fluorobenzaldehyde

triethylamine

→

title compound

Rendimiento 92.0%

ethyl 6-bromobenzo[b]thiophene-2-carboxylate

Rendimiento 92.0%

Disolventes

DMSO

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe mixture was partitioned between H2O (50 mL) and CH2Cl2 (2×50 mL)
2. 2
   Secadothe combined organic layers were dried over Na2SO4
3. 3
   FiltraciónThe drying agent was filtered off
4. 4
   Otrothe solvent was removed in vacuo

Procedimiento

A solution of ethyl thioglycolate (0.65 g, 5.42 mmol), 4-bromo-2-fluorobenzaldehyde (1.0 g, 4.93 mmol) and triethylamine (1.25 mL, 12.3 mmol) in DMSO (5 mL) was heated at 75° C. for 2 h. The mixture was partitioned between H2O (50 mL) and CH2Cl2 (2×50 mL), and the combined organic layers were dried over Na2SO4. The drying agent was filtered off, and the solvent was removed in vacuo to give the title compound as an oil (1.29 g, 92%).

Fuente