Reacción #1973973

Ecuación de reacción

methyl 4-bromo-2-(bromomethyl)benzoate

(2,4-dimethoxyphenyl)methanamine

triethylamine

→

title compound

Rendimiento 44.2%

5-bromo-2-(2,4-dimethoxybenzyl)isoindolin-1-one

Rendimiento 44.2%

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe resulting solid was filtered off
2. 2
   Concentraciónthe filtrate was concentrated in vacuo
3. 3
   OtroThe crude product was purified by column chromatography on silica gel using 1:4 EtOAc

Procedimiento

To a solution of methyl 4-bromo-2-(bromomethyl)benzoate (1.0 g, 3.25 mmol) and (2,4-dimethoxyphenyl)methanamine (0.65 g, 3.90 mmol) in THF (16 mL) was added triethylamine (0.91 mL, 6.5 mmol), and the resulting mixture was stirred at room temperature for 16 h. The resulting solid was filtered off, and the filtrate was concentrated in vacuo. The crude product was purified by column chromatography on silica gel using 1:4 EtOAc:hexanes as the eluent to give the title compound as a colorless solid (0.52 g, 44%).

Fuente