Reacción #1973970

Ecuación de reacción

2-bromo-1-methoxy-4-nitrobenzene

sodium 2,2,3,3,3-pentafluoropropanoate

→

1-methoxy-4-nitro-2-(perfluoroethyl)benzene

Disolventes

DMF

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroto give a tan suspension
2. 2
   Otrotoluene was removed by a Dean-Stark trap
3. 3
   TemperaturaThe mixture was heated at 155° C. for 6 h under nitrogen
4. 4
   Temperaturacooled
5. 5
   workup.ADDITIONpoured into 100 mL of water and 100 mL of ether
6. 6
   Filtraciónfiltered through a 1-inch plug of Celite
7. 7
   Lavadothe plug was rinsed with ether
8. 8
   OtroThe filtrate layers were separated
9. 9
   LavadoThe organic layer was washed with brine
10. 10
    Secadodried (Na2SO4)
11. 11
    Filtraciónfiltered
12. 12
    Concentraciónconcentrated
13. 13
    Otrochromatographed on an Isco 40 g silica cartridge
14. 14
    Lavadoeluting with 4:1 hexane/EtOAc
15. 15
    Otroto give a yellow oil that
16. 16
    workup.ADDITIONmix of desired material

Procedimiento

To a 250 mL round-bottom flask was added 2-bromo-1-methoxy-4-nitrobenzene (3.5 g, 15.08 mmol), copper(I) iodide (5.75 g, 30.2 mmol), and sodium 2,2,3,3,3-pentafluoropropanoate (5.25 g, 28.2 mmol) in DMF (75 ml) and toluene (25 ml) to give a tan suspension. The mixture was heated at 150° C. and toluene was removed by a Dean-Stark trap. The mixture was heated at 155° C. for 6 h under nitrogen, cooled and poured into 100 mL of water and 100 mL of ether, filtered through a 1-inch plug of Celite and the plug was rinsed with ether. The filtrate layers were separated. The organic layer was washed with brine, dried (Na2SO4) filtered and concentrated. The dark oil was flash chromatographed on an Isco 40 g silica cartridge eluting with 4:1 hexane/EtOAc to give a yellow oil that was a (3:1) mix of desired material and starting material (1.5 g, 37%).

Fuente