Reacción #1973924

Ecuación de reacción

Bupivacaine hydrochloride

sodium hydroxide

→

Bupivacaine

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroto precipitate the Bupivacaine base
2. 2
   FiltraciónThe precipitated product was filtered
3. 3
   Lavadofurther washed with DI water for at least three times
4. 4
   OtroThe precipitated product was dried at ca. 40° C. in vacuum for 24 hours

Procedimiento

Bupivacaine hydrochloride (Sigma-Aldrich Corporation, St. Louis, Mo.) was dissolved in de-ionized (DI) water at a concentration of 40 mg/ml (saturation). A calculated amount of sodium hydroxide (in the form of 1 N solution) was added to the solution and the pH of the final mixtures was adjusted to ten to precipitate the Bupivacaine base. The precipitated product was filtered, and further washed with DI water for at least three times. The precipitated product was dried at ca. 40° C. in vacuum for 24 hours.

Fuente