Reacción #1968407

Ecuación de reacción

(3-Chloro-5,6-dihydroxy-benzo[b]thiophen-2-yl)-(2,6-dimethyl-morpholin-4-yl)-methanone

HNO3

→

(3-Chloro-5,6-dihydroxy-7-nitro-benzo[b]thiophen-2-yl)-(2,6-dimethyl-morpholin-4-yl)-methanone

Disolventes

ethyl acetate

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe mixture was concentrated to smaller volume
2. 2
   Filtraciónthe precipitate filtered
3. 3
   Lavadowashed with water
4. 4
   OtroThe crude product was recrystallized from N,N-dimethylformamide/ethanol (25:75)

Procedimiento

(3-Chloro-5,6-dihydroxy-benzo[b]thiophen-2-yl)-(2,6-dimethyl-morpholin-4-yl)-methanone (0.20 g) was dissolved in ethyl acetate and 1 N HNO3 solution in dichloromethane (0.64 ml) was added. Stirring was continued for 4 hours. The mixture was concentrated to smaller volume and the precipitate filtered and washed with water. The crude product was recrystallized from N,N-dimethylformamide/ethanol (25:75).

Fuente