Reacción #1960503

Ecuación de reacción

7,8-difluoro-3-trimethylsilanylnaphthalen-2-ol

bromoethane

potassium carbonate

→

(3-ethoxy-5,6-difluoronaphthalen-2-yl)trimethylsilane

Disolventes

ethyl methyl ketone

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe batch is filtered
2. 2
   Lavadothe residue is washed with ethyl methyl ketone
3. 3
   ConcentraciónThe filtrate is concentrated
4. 4
   LavadoThe solution is washed with water and sat. sodium chloride soln
5. 5
   Otroand dried
6. 6
   Otroafter removal of the solvent
7. 7
   Otrois purified by column chromatography (SiO2, toluene:ethyl acetate=9:1)

Procedimiento

54.7 g (about 0.12 mol) of 7,8-difluoro-3-trimethylsilanylnaphthalen-2-ol are stirred at 80° C. for 19 h together with 19.5 ml (0.26 mol) of bromoethane and 34.5 g (0.25 mol) of potassium carbonate in 400 ml of ethyl methyl ketone. The batch is filtered, and the residue is washed with ethyl methyl ketone. The filtrate is concentrated, and the residue is taken up in MTBE. The solution is washed with water and sat. sodium chloride soln. and dried using sodium sulfate. The residue remaining after removal of the solvent is purified by column chromatography (SiO2, toluene:ethyl acetate=9:1), giving (3-ethoxy-5,6-difluoronaphthalen-2-yl)trimethylsilane as a dark-brown solid.

Fuente