Reacción #1929062

Ecuación de reacción

HCl

potassium hydrogen carbonate

6-(chloracetamido) hexanoic acid

potassium cyanide

→

6-(cyanacetamido)hexanoic acid

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas cooled on ice
2. 2
   ExtracciónThe residue after extraction
3. 3
   Otrowas purified by chromatography (silica gel, solvent: ethyl acetate)

Procedimiento

2.8 g (20 mMol) potassium hydrogen carbonate was added to 8.3 g (40 mMol) 6-(chloracetamido) hexanoic acid dissolved in 25 ml water. 3.2 g (48 mMol) potassium cyanide was then added to the clear solution which was cooled on ice. The reaction mixture was stirred for 17 hours and was then acidified with HCl (2 N). The residue after extraction was purified by chromatography (silica gel, solvent: ethyl acetate).

Fuente