Reacción #1929004

Ecuación de reacción

compound ( 48 )

4-bromo-1-[5-(trifluoromethyl)-2-pyridyl]piperidine

sodium hydride

DMF

compound ( 46 )

2-propoxy-4-(trifluoromethyl)benzenethiol

→

4-[2-propoxy-4-(trifluoromethyl)phenylsulfanyl]-1-[5-(trifluoromethyl)-2-pyridyl]piperidine

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas heated to 100° C.
2. 2
   workup.STIRRINGwas then stirred for 1 hour
3. 3
   TemperaturaAfter the mixture was cooled
4. 4
   Extracciónwas then subjected to extraction with ethyl acetate
5. 5
   LavadoAfter its organic layer was washed with water
6. 6
   Secadowas then dried with anhydrous magnesium sulfate, it
7. 7
   Filtraciónwas filtered
8. 8
   Concentraciónwas then concentrated under reduced pressure
9. 9
   OtroIts residue was purified by column chromatography
10. 10
    Otroto produce the chemical compound

Procedimiento

After 60% sodium hydride was added, with chilling on ice, to the DMF (7 ml) solution of the chemical compound (46) (0.62 g), it was warmed to room temperature, and was then stirred for 30 minutes. After the chemical compound (48) (0.74 g) was added to the mixture, it was heated to 100° C., and was then stirred for 1 hour. After the mixture was cooled, it was poured into water, and was then subjected to extraction with ethyl acetate. After its organic layer was washed with water, and was then dried with anhydrous magnesium sulfate, it was filtered, and was then concentrated under reduced pressure. Its residue was purified by column chromatography to produce the chemical compound mentioned in the above title (0.90 g).

Fuente