Reacción #1929003

Ecuación de reacción

Sodium borohydride

( 28 )

N-benzyl-3-azabicyclo[3.3.1]nonane-9-one

→

crude compound ( 29 )

Rendimiento 191.5%

N-benzyl-3-azabicyclo[3.3.1]nonane-9-ol

Rendimiento 191.5%

N-benzyl-3-azabicyclo[3.3.1]nonane-9-one

Disolventes

MeOH

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawith chilling on ice
2. 2
   Temperaturawith chilling on ice, its solvent
3. 3
   Otrowas evaporated under reduced pressure
4. 4
   workup.ADDITIONWater was added to its residue, which
5. 5
   Extracciónwas then subjected to extraction with methylene chloride
6. 6
   Secadoby drying its organic layer with anhydrous magnesium sulfate
7. 7
   OtroIts solvent was evaporated under reduced pressure

Procedimiento

N-benzyl-3-azabicyclo[3.3.1]nonane-9-one (28) was synthesized according to a method described in J. Med. Chem. 1994, 37, 2831-2840. Sodium borohydride (1.49 g) was added into the MeOH (80 ml) solution of (28) (6.75 g) with chilling on ice. After its mixture was stirred for 1 hour with chilling on ice, its solvent was evaporated under reduced pressure. Water was added to its residue, which was then subjected to extraction with methylene chloride, followed by drying its organic layer with anhydrous magnesium sulfate. Its solvent was evaporated under reduced pressure to produce a crude compound (29) (6.52 g).

Fuente