Reacción #1925214

Ecuación de reacción

acetic anhydride

N,N-bis(2-hydroxyethyl)-2-(methoxycarbonyl)ethylamine

triethylamine

THF

→

N,N-bis(2-acetoxyethyl)-2-(methoxycarbonyl)ethylamine

Rendimiento 99.0%

Disolventes

Water

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroto terminate
2. 2
   Otrothe reaction
3. 3
   ExtracciónThe reaction mixture was extracted with ethyl acetate
4. 4
   LavadoThe organic layer was then washed with water
5. 5
   Secadodried over anhydrous sodium sulfate
6. 6
   ConcentraciónAfter concentration under reduced pressure
7. 7
   workup.DISTILLATIONthe residue was purified by distillation under reduced pressure

Procedimiento

At 20 to 30° C., acetic anhydride was added to a mixture of 9.29 g of N,N-bis(2-hydroxyethyl)-2-(methoxycarbonyl)ethylamine, 12.8 g of triethylamine, 50 mg of 4-dimethylaminopyridine and 50 ml of THF and the resulting mixture was stirred for 20 hours. Water was added to terminate the reaction. The reaction mixture was extracted with ethyl acetate. The organic layer was then washed with water and dried over anhydrous sodium sulfate. After concentration under reduced pressure, the residue was purified by distillation under reduced pressure, whereby 13.2 g of N,N-bis(2-acetoxyethyl)-2-(methoxycarbonyl)ethylamine was obtained (boiling point: 118 to 123° C./21 Pa, yield: 99%).

Fuente