Reacción #1918874

ord-b3a9570187cb4e75a4418190c95f5beb

Ecuación de reacción

CCC(CC)Nc1cc(C)nc(Cl)c1C(=O)O
2-chloro-4-(1-ethyl-propylamino)-6-methyl-nicotinic acid
Cc1ccccc1N(C)C
trimethylaniline
O=C([O-])[O-].[K+].[K+]
potassium carbonate
CN(C)C=O
DMF
→
CCC(CC)Nc1cc(C)nc(Nc2c(C)cc(C)cc2C)c1C(=O)O
desired product
CCC(CC)Nc1cc(C)nc(Nc2c(C)cc(C)cc2C)c1C(=O)O
4-(1-Ethyl-propylamino)-6-methyl-2-(2,4,6-trimethyl-phenylamino)-nicotinic acid

Reactantes

CCC(CC)Nc1cc(C)nc(Cl)c1C(=O)O
2-chloro-4-(1-ethyl-propylamino)-6-methyl-nicotinic acid
Cc1ccccc1N(C)C
trimethylaniline
O=C([O-])[O-].[K+].[K+]
potassium carbonate
CN(C)C=O
DMF

Reactivos

[Cu]
copper

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroThe title compound was prepared

Procedimiento

The title compound was prepared by heating 2-chloro-4-(1-ethyl-propylamino)-6-methyl-nicotinic acid and trimethylaniline in the presence of potassium carbonate and copper in DMF. The desired product was isolated by silica gel column chromatography using 5% methanol in chloroform as solvent to give a tan solid, mp. 130–135° C.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07067664B1uspto-grants-2006_06