Reacción #1910378

Ecuación de reacción

Methyl 6-bromo-2-naphthalene carboxylate

Potassium carbonate

water

2,4,6-trivinylcyclotriboroxane-pyridine complex

→

methyl 2-vinyl-6-naphthalene carboxylate

Rendimiento 98.1%

Disolventes

dimethoxyethane

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGthe mixture was stirred for 24 hours
2. 2
   Temperaturawhile refluxing
3. 3
   Temperaturawith heating
4. 4
   TemperaturaThere action mixture was cooled to room temperature
5. 5
   workup.ADDITIONtreated with activated alumina

Procedimiento

Methyl 6-bromo-2-naphthalene carboxylate (98 g) was dissolved in dimethoxyethane (2 1) and tetrakis(triphenylphosphine)palladium (44 g) was added in nitrogen atmosphere. The mixture was stirred for 30 minutes at room temperature. Potassium carbonate (52 g), water (1 1) and 2,4,6-trivinylcyclotriboroxane-pyridine complex (91 g) were added and the mixture was stirred for 24 hours while refluxing with heating. There action mixture was cooled to room temperature and treated with activated alumina to obtain methyl 2-vinyl-6-naphthalene carboxylate (77 g).

Fuente