Reacción #1904038

Ecuación de reacción

aspartic acid

triethyl amine

succinyl chloride

→

Aspartic Acid Succinimide

Disolventes

tetrahydrofuran

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrofitted with a condenser and nitrogen inlet
2. 2
   Temperaturarefluxed for 6 hours
3. 3
   FiltraciónThe triethyl amine hydrochloride is filtered
4. 4
   Concentraciónthe filtrate is concentrated
5. 5
   Otroby removing the solvent under vacuum
6. 6
   OtroThe residue is used directly for the subsequent reaction
7. 7
   OtroThe residue can be purified by chromatography on silica gel

Procedimiento

This example that demonstrates how this method could be performed. 9.4 g aspartic acid, 10 ml triethyl amine and 100 ml tetrahydrofuran are transferred into a 100 ml flask fitted with a condenser and nitrogen inlet. The mixture is cooled to 0° C. and 5 g succinyl chloride is added and the mixture stirred under nitrogen atmosphere for 5 min and refluxed for 6 hours. The triethyl amine hydrochloride is filtered and the filtrate is concentrated by removing the solvent under vacuum. The residue is used directly for the subsequent reaction. The residue can be purified by chromatography on silica gel.

Fuente