Reacción #1903

Ecuación de reacción

4-bromo-3-methoxyphenol

benzyl bromide

potassium carbonate

→

4-benzyloxy-2-methoxybromobenzene

Disolventes

acetone

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe insoluble materials were removed by filtration
2. 2
   Concentraciónthe filtrate was concentrated in vacuo
3. 3
   OtroThe residue was purified by silica gel column chromatography (hexane:ethyl acetate=20:1)

Procedimiento

A mixture of 4-bromo-3-methoxyphenol (21 g), benzyl bromide (13.5 ml), potassium carbonate (21.4 g) and acetone (200 ml) was stirred at room temperature for 24 h. The insoluble materials were removed by filtration and the filtrate was concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=20:1) to give 4-benzyloxy-2-methoxybromobenzene (25 g) as an oil.

Fuente