Reacción #1901053

Ecuación de reacción

n-butyllithium

2-bromopyridine

trimethyltin chloride

THF

→

title compound

Rendimiento 51.0%

2-Trimethylstannylpyridine

Rendimiento 51.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGThe reaction was stirred for 1 h at −78° C.
2. 2
   Filtraciónfiltered
3. 3
   Otrothe filtrate evaporated
4. 4
   workup.DISTILLATIONDistillation

Procedimiento

A solution of 15.7 mL of 1.6 M n-butyllithium (25.1 mmol) in anhydrous other (25 mL) was stirred under Ar at −78° C. and to this was added a solution of 2-bromopyridine (3.97 g, 25.1 mmol) in anhydrous other (12.5 mL). The resulting orange solution was stirred for 2 h, and trimethyltin chloride in THF (26.0 mmol, 26 and, 1.0 M) added over 30 min. The reaction was stirred for 1 h at −78° C. then warmed to room temperature over 1 h, filtered and the filtrate evaporated. Distillation afforded 3.1 g (51%) of the title compound as a colorless liquid which solidified in the receiver flask. B.p. 65° C./2 mm Hg; Literature B.p. 75° C./4 mm Hg.

Fuente